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Treatment depends on whether the pain is caused by vascular compression near the brainstem, irritation of trigeminal nerve branches in the face, dental or surgical injury, viral nerve damage, central sensitization, or overlapping contributing factors

Massicot F, Martin C, Dutertre-Catella H, Ellouk-Achard S, Pham-Huy C, Thevenin M, et al

Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force

There was no significant difference in the cytotoxic effects of 3-BP between cetuximab-resistant cell lines (HCT116(KRAS G13D/- ), DLD-1(KRAS G13D/- ), HT29(BRAF V600E ), RKO(BRAF V600E/-/- ), Caco-2-CR) and their paired cetuximab-sensitive cell lines (HCT116(KRAS wt/- ), DLD-1(KRAS wt/- ), HT29(shBRAF), RKO(BRAF wt/-/- ), Caco-2), indicating that the cytotoxic effect of 3-BP in these CRC cell lines is independent of their response to cetuximab